This chapter deals with the exercise of power in the international political economy through economic statecraft; it is divided into six sections: the first focuses on economic statecraft as an academic field, making the case for “thick” economic statecraft; the second reviews the political and power dimensions of US economic statecraft, whereas the third deals with the practice of US economic statecraft in general. Section four focuses on the evolution, since the 1970s, of the paradigmatic instance of US economic statecraft: trade policy, broadly defined. The fifth section is devoted to the operationalization of the concept of power in the economic realm, as understood by a thick economic statecraft approach; the sixth section presents a summary of the discussion.