ABSTRACT
This chapter focuses on the administration and reviews stages of the catastrophic disease process. The authors believe that optimal functioning at the stages of administration and review will to a great extent be determined by the care which has been taken in formulating policies. Once policies are better formulated, decisionmakers at the administration stage should be able to appreciate with greater certainty not only the limits within which they may operate but also the extent of their freedom to operate. In basic policy deliberations on how to guide the administration of both experimentation and therapy, persons from outside biomedicine have an important role to play in representing and championing those values which affect individual and societal rights and interests. The Institutional Advisory Committees (IAC) has the responsibility of assuring that adequate information is available to the reviewing bodies and that the "larger issues" raised by the biomedical enterprise are addressed publicly.
