ABSTRACT
For some, certain intrinsic or extrinsic factors may alter this course and delay or prevent the healing process. In these cases, destructive processes override healing, and the wound becomes chronic. Fibrin also holds the edges of the wound together; if left exposed, the surface of the clot dries, forming a scab. The granulation tissue that is seen in wounds results from capillary and fibroblast proliferation. The restoration of dermal architecture by collagen fibres eventually enables wounds to have strength that is similar to that of unaffected skin. Chronic wounds are most often associated with underlying or exogenous abnormalities that lead to tissue breakdown and ulceration, with venous leg ulcers, diabetic foot ulcers and decubitus ulcers being examples of chronic wounds commonly seen in clinical practice. Components of Aloe vera gel have been shown to significantly enhance keratinocyte proliferation and migration in wounds with the cell proliferation-stimulatory activity shortening healing time.
