ABSTRACT
Nanorobotics often integrates nanotechnology and robotics with the aim of developing new tools and instruments for specic applications. Nanotechnology is attractive in this respect since the physics inherent to nanoscale entities differ signicantly from those at the macroscale. Hence, by exploiting the forces and phenomena that operate at both scales, the range of possibilities for generating solutions at the engineering level (where the laws of physics are applied) may be enhanced considerably. When targeted medical interventions
CONTENTS
14.1 Introduction ...................................................................................................................... 517 14.2 Recent Targeted Delivery Drug Carriers ...................................................................... 518 14.3 Improved Targeting Strategies ....................................................................................... 519 14.4 Principal Constraints for Controlled Navigation within the Vascular Network ... 519 14.5 Overview of Potential Methods of Transport within the Vascular Network ......... 520 14.6 Magnetic Microcarriers ................................................................................................... 521 14.7 Magnetic Resonance Navigation (MRN)...................................................................... 521 14.8 Fundamental Principles of MRN ................................................................................... 522 14.9 Fundamental Theory of MRN ....................................................................................... 524 14.10 MRI as Imaging Modality for MRN ............................................................................. 526 14.11 Ideal Closed-Loop MRN Control .................................................................................. 527 14.12 Deviations from Ideal Closed-Loop MRN Control..................................................... 528 14.13 Therapeutic Magnetic Microcarriers ............................................................................ 529 14.14 Perspective of MRN for Targeted Cancer Therapy ..................................................... 531 14.15 Perspective of TMMC for Clinical Interventions ........................................................ 532 14.16 Propulsion within the Microvasculature ..................................................................... 533 14.17 ABF-Based Microcarriers ................................................................................................ 533 14.18 Steerable Self-Propelled Entities as Therapeutic Carriers ..........................................534 14.19 Applicability of MRN Therapeutic Agents .................................................................. 537 14.20 Applicability of MTB-Based Therapeutic Agents ....................................................... 538 14.21 Combining MRN with MTB-Based Approaches ........................................................ 539 14.22 Conclusion ........................................................................................................................ 539 14.23 To Probe Further ..............................................................................................................540 References .....................................................................................................................................540
