ABSTRACT

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly, with alarming increases in the number of patients in recent years. Of the many therapeutics tested to overcome symptoms of this disease to date, bioactive plant chemicals, such as quercetin, play a pivotal role in alleviating AD symptoms. Quercetin shows multiple therapeutic benefits against numerous diseases. However, several studies have shown that quercetin shows low solubility and that its administration induces adverse side effects, such as breast cancer, etc. To overcome these challenges associated with quercetin administration, nanotechnological delivery systems, such as gold-palladium tethered concave cubic formulation, and liposomal formulations have been developed. This chapter primarily focuses on the role in neuroprotection of quercetin, its salt forms and various nanoformulations.