ABSTRACT
The main pathophysiological mechanism of ovarian hyperstimulation syndrome (OHSS) is increased vascular leakage from the ovaries as well as within the peritoneal lining of the abdominal and thoracic sinuses. This pro nounced plasma leakage to the third compart ment induces hypovolemia, and because of sec ondary tissue hypoperfusion, the syndrome may escalate to multiple organ failure. There may also be activation of the coagulation cascade, with the development of thrombosis in large vessels.
