The relatively easy rearing protocols available for anemonefishes make them a great model for performing aquarium-based manipulative experiments and studying the potential of coral reef fishes to acclimate, adapt, or move in response to anthropogenic stressors such as climate change. Multiple clutches are produced within a breeding season, and they are therefore also a good model for transgenerational studies. Many aspects of the whole life history of anemonefish are still mysterious. The larval stage is probably the most vexing enigma in this area. It is very difficult to imagine how the larvae can survive in the pelagic environment when they are very sensitive to condition changes in laboratory husbandries. Anemonefishes have the potential to provide the first reliable understanding of the extinction risks of marine fishes and the effectiveness of actions taken to minimize these risks.