The human body of wireless users at present plays an extremely limited role in both the network and the user terminal functions and architectures. An innovative and challenging vision of the 5G-to-6G transition envisages the human body as a main actor with an active role in node and network functions as well as in user terminal architecture. Mobile information systems have been facing the challenges of the continuously increasing demand for the high data rates and mobility required by new wireless applications. Research on 5G wireless communications has started and developed rapidly. It is expected that 5G wireless infrastructure will be deployed beyond 2020. Massive MIMO technologies have been proposed to scale up data rates reaching gigabits per second in the forthcoming 5G mobile communications systems. Compressive sensing theory can be applied to reconstruct the signal with far fewer measurements than what is usually considered necessary.