ABSTRACT
The purpose of this study was to determine the histopathological change of endometrium of white rats infected with different concentration of E. coli. For that purpose, 9 white rats were randomly divided into 3 treatment groups consisted of 3 rats each. The rats in control group (P0) was inoculated with NaCl solution, while the rats in group I (PI) and group II were inoculated with E. coli at concentration of 1.0 × 105 CFU/ml and 1.5 × 108 CFU/ml, respectively. The rats were sacrificed 36 hours post inoculation to evaluate the histophatological change in endometrium. Data were analyzed using the Kruskal-Wallis non-parametric test and continued with the Mann-Whitney U test. The results showed that the level of necrosis and proliferation of endometrial epithelial cells were significantly higher (P<0.05) in groups PI and PII as compared to group P0. It could be concluded that the higher the concentration of inoculated E. coli, the higher the damage to the endometrium in terms of the decrease in lumen size, the level of necrosis and proliferation of endometrial epithelial cells.
