ABSTRACT
Electrospinning is a promising approach for synthesizing polymeric nanofibers with diverse applications in drug delivery systems. This chapter focuses on the design and characterization processes of electrospun-based nanoformulations, together with their complexities. Various electrospinning-based nanoformulations, including drug-loaded and core-shell structures, are explained in detail, emphasizing the design concept, type of polymer used, and fundamental mechanisms that control their functionality. Among these, nano-sized formulations include antimicrobial nanofibers designed to combat infections and biodegradable nanofibers that support tissue engineering and controlled release of medication. Fabrication methods like blend, coaxial, and melt techniques are mainly discussed along with the necessary modifications related to polymeric solvents and electrospinning equipment to achieve optimal nanofibers with certain qualities in this chapter. Furthermore, critical aspects affecting the effectiveness of electrospun-produced nanofibers and the accurate characterization methods including morphological study, structural elucidation, drug release profile for assessment are discussed. Over all, this chapter reveals the possibilities linked to electrospinning for both nanotechnology and medicine combinedly.
