The centralization of data is a current practice in information systems that do not fit into the novel next-generation computing concept. Such a paradigm aims to support the distribution of information, processing, and computing power. Blockchain is a technology supporting the recording of information for distributed and decentralized, peer-to-peer applications, which has emerged in the last decade, with the initial focus being on the finance sector. A highly valuable feature of blockchain is its capability of enhancing the security of data due to the immutability of the information stored on the ledger. In this chapter, the definition, details, applications, and benefits of this technology will be explored. In addition, the ways in which blockchain increases security and privacy will be described. Finally, the pairing of blockchain with other next-generation, cutting-edge technologies will be investigated.