ABSTRACT
In this chapter, the incorporation of fluorine and zinc as well as the effects of such incorporation are introduced and discussed. To satisfy both the requirements of dissolution resistancy and bone formation stimulatory, fluorine- and zinc-substituted Hydroxyapatite (HA) could be a good alternative, if they could be incorporated in an appropriate manner. As fluorine can improve the solubility of HA and play an important role in biological mineralization as well, fluorine-doped Hydroxyapatite has attracted widespread concern. Fluorine can be introduced into the film via fluorine-containing reagents, such as trifluoroacetic acid, hexafluorophosphoric acid, and ammonium hexafluorophosphate. With the increase of fluorine content, the relative crystallinity significantly increased. With different fluorine content, the morphology of films after immersion also had some changes. Films with lower fluoride content became rougher, and more grains were observed on the surface, while films with higher fluorine content appeared rather smooth.
