This chapter provides a history of administrative pharmaceutical regulation from independence to the present in Ghana, Côte d'Ivoire, and Benin. It highlights the evolution of the pharmaceutical regulatory system in the three countries and the different choices that have been made in terms of medicines supply and support for local pharmaceutical production by the States. It also takes into account the influence of transnational actors in the various reform movements at work, which tend to create agencies with relative autonomy from the State. This chapter seeks to demonstrate how local production plays an important role in the strengthening of State pharmaceutical regulation and contributes to the construction of countries' pharmaceutical sovereignty.