This chapter introduces the themes of the book and provides an overview of key arguments and of the chapters in the book. Among other things, the chapter discusses the problem of knowledge resistance, outlines the purpose of the book, and provides a broad framework toward understanding knowledge resistance and its antecedents. This framework includes the transition from low- to high-choice media environments, an increase in the prevalence of mis- and disinformation, biased information processing, and factual belief polarization, and the linkage between misperceptions and knowledge resistance. Finally, it briefly introduces and discusses each of the chapters in the book.