ABSTRACT
In the context of global clinical research, cultural differences between researchers and potential participants in clinical trials could result in communication barriers. Community engagement is, in fact, a key aspect for designing a culturally appropriate informed consent process, including community perspective, and safeguarding individual autonomy. The chapter starts with discussing the main challenges to the informed consent process in a multicultural setting. It highlights community engagement ethical goals (protecting local communities, improving research quality, and building trust), exploring international recommendations, and identifying main strategies on this subject. The chapter finally suggests considering the process of involving community members in the informed consent process to move towards a relational view of autonomy.
