For decades, the United States had concerns about the European strategic autonomy, especially in the military domain. The Trump administration often reminded European leaders that NATO, not the European Union, is the key to the Western military alliance. Joe Biden, on the other hand, highlights that a strong EU remains in the US’s interest. This chapter examines how the US approaches the EU moves towards strategic autonomy. Has the US approach towards the EU strategic autonomy been dynamic? What concept of the ESA would the US find acceptable or even beneficial? How might the pursuit of ESA possibly affect the relations between the US and EU? These are the questions that the chapter aims to address.