ABSTRACT
Here, I look at how fliponware, codonware, and wetware work together to produce specific outcomes. Triggering these events requires the folding of nucleic acid into a highly conserved structure recognized by the protein machinery that does the work of a cell.
I also show that junk repeat sequences, a subset of which are flipons, can also code for peptide patches that allow the reuse, in different ways, of proteins with highly evolved functions. I examine how these peptides contribute to the formation of membraneless condensates to create functional compartments in the nucleus and cytoplasm. I look at how these processes organize the cell and lead to the creation of the protein, lipid, and non-templated molecular scaffolds that regulate cell signaling, autophagy, and programmed cell death pathways. I discuss their impact on disease and cellular senescence.
