Does Z-DNA Regulate Transcription?

Here, I discuss Z-DNA flipons further, detailing their mapping on the genome and how they can facilitate the reset of genes to control the level of gene expression. The role of nucleosomes, acting as batteries to store energy and regulate Z-DNA formation, is presented. The effects of Z-DNA on chromatin structure and the role of Z-DNA in the localization of ADAR1 to edit RNA transcripts prior to splicing is explored. The idea that genetic information could be encoded by sequences that form alternative conformations is then examined in more depth