ABSTRACT

The analgesic naproxen comes in two forms, one that is toxic and one that is beneficial for relieving pain. Enzymes will only interact with naturally occurring sugars, proteins, and DNA/RNA, and if you were to go into a mirror world, your enzymes would not be able to interact with any mirror molecules. Both of these phenomena occur because molecules are not flat, but they have three-dimensional structures. The electronic geometry around an atom can be predicted according to valence shell electron pair repulsion (VSEPR) theory, which relies on identifying the number of areas of electron density (attached atoms and lone pairs). In this chapter, idealized molecular geometries and factors that distort molecules away from these idealized shapes are considered, along with tools for properly conveying three-dimensional shapes via two-dimensional media.