ABSTRACT
The utilization of genomics data has been used to accelerate drug development. The combined approach of both bioinformatics and genomic analysis has considerably improved the current understanding of the pathogenesis and mechanisms of many infectious diseases. Various conceptual approaches and computer-aided techniques assist target identification, target prioritization, and tractability. Bioinformatics tools facilitate the methods for examination of genomic data, aiming to identify and validate new therapeutic targets. A wide range of software, databases, and web services related to drug discovery are available to find genes, proteins, or pathways that are involved in causing disease. These targets then undergo a thorough pharmacological validation procedure to verify their significance and suitability for therapeutic intervention. This chapter provides a brief overview of bioinformatics tools and techniques used in the analysis of genomic data for drug development. We discuss different processes and applications that are currently used for drug development, which include target identification, personalized medicine, drug repurposing, and toxicity prediction. Additionally, we explore the challenges and innovative solutions in applying bioinformatics to drug development, such as the crucial requirement for standardization, unlocking insights from complex data, and harnessing the power of integrated analytics.
