ABSTRACT
Objectives: This systematic review aims to determine the efficacy of hydroxyapatite-containing product compared to fluoride, as caries prevention in children. Methods: A systematic search with PICO frameworks and PRISMA guidelines was conducted on article published 10 years prior in PubMed, Scopus, and EBSCO databases, using keywords: hydroxyapatite, fluoride, caries, primary teeth. The inclusion criteria were human clinical trial studies, caries prevention, children, and include both hydroxyapatite and fluoride on all form of preparation. Risk of Bias 2.0 tool was used to assess the included studies. Results: A total of 6 studies with low risk of bias, were included in the review. The included studies were analyzed using vote counting direction of effect. The 5 included studies shown that hydroxyapatite containing product had the same efficacy as fluoride for caries preventing agent. Conclusions: There is good evidence that hydroxyapatite-containing product is as effective as fluoride for preventing caries in children.
