ABSTRACT
Objectives: To evaluate the potential of S. littoralis stem extract as a local hemostatic agent. Methods: In vivo and in vitro laboratory experiments were conducted on 18 SD rats divided into six treatment groups: negative control (no treatment), positive control (tranexamic acid), S. littoralis stem extract with concentrations of 25%, 50%, 75%, and 100%. Results: This study showed that S. littoralis stem extract with concentrations of 50%, 75%, and 100% was proven to have the ability to accelerate bleeding time, prothrombin time, and activated partial thromboplastin time with the 100% had the fastest local hemostatic activity. ANOVA One Way test revealed significant differences between the treatment groups in the BT, PT, and aPTT tests (p<0.05). The post hoc test confirmed that the 100% extract was as effective as the positive control, 500mg/mL tranexamic acid. Conclusion: S. littoralis stem extract has the potential to be a local hemostatic agent.
