ABSTRACT
Objectives: to examine the histopathological features of macrophages and fibroblasts post-tooth extraction following treatment with a combination of HA and L. reuteri gel. Methods: Probiotic lozenges and HA gel will be applied separately as a combination treatment on White male Wistar rats (Rattus norvegicus), and assessed on days 3, 7, and 14 post-left mandibular central incisor extraction. Macrophages and fibroblasts were analyzed histopathological using H&E staining. Results: The combination treatment group show significant differences in the number of macrophages compared with the other treatment groups divided into five group days 3, 7, and 14 (P<0.05) and show a significant difference in fibroblast proliferation (P<0.05), with the number of fibroblasts significantly increasing on days 3 and 7, followed by accelerated proliferation on day 14 which was marked a reduction of fibroblasts. Conclusion: L. reuteri combined with HA have potential ability to promote wound healing post-tooth extraction.
