Demineralized Dentin Matrix from human teeth to accelerate bone regeneration

Objectives: Evaluating the effect of Demineralized Dentin Matrix (DDM) gel on the expression of the number of fibroblast cells and the density of type 1 collagen. Methods: A total of 18 guinea pigs were extracted from the left incisive mandibular and then divided into control groups and treatment groups and euthanasia for sawing the number of fibroblast cells and the density of type 1 collagen on the 7^th, 14^th, and 21^st days. Data analysis using Oneway ANOVA (p<0.05) and type I collagen density were analyzed using the Kruskal Wallis test (p<0.05). Results: There is a significant difference between the treatment group and control with the significance value in the average density of type 1 collagen (0.009) and the fibroblast cells (0.001). Conclusion: DDM has the effect of increasing fibroblast cells and density of type I collagen on the -7^th, -14^th, and -21^st days, and might accelerate with the increase of bone remodeling.