As soon as the NRTs emerged there were cries of concern. This chapter examines initial responses from feminists and organized religions along with those from LGBTQ2+ communities – all who had arguments critical of the developments and calling for some form of protection of reproductive rights and values. The second section examines how some of these concerns expanded into matters of reproductive justice weighing out the complexity of interests involved and intersections between people marginalized by race, geopolitical location, class and sexual identity. Finally, genetics and a key recent development that holds out great financial promise are examined in terms of the biomedicalization of reproduction and replication.