ABSTRACT

Describing and understanding the effects of combining two or more drugs, two or more substrates, and in general two or more ligands has challenged a broad segment of scientists in a number of research fields (Berenbaum 1989; Greco et al. 1995; Tallarida 2000, 2007; White et al. 2003; Chou 2006; Lee et al. 2007; Brun et al. 2007). Table 12.1 lists some examples of drug combinations from the human disease field that cover therapies for cancer, AIDS, and auto-immunological diseases, such as asthma, diabetes, inflammatory bowl disease, and rheumatoid arthritis, as well as many others. For multi-drug treatment or survival of other organisms there is, for instance, the use of fertilizers, pesticides and weed killers.