Natural information shall be an objective commodity and also allow for the possibility of being relevant in different ways to different consumers. This chapter outlines the concepts of natural information and of informational domains that are the best way to go, and then very briefly recapitulate the lessons to be learned from Dretske's and Gibson's notions of information. It discusses Millikan's "domains" of natural information. The first and the second of the ways of carving out domains of natural information are the ones Millikan has in mind, whereas the third seems to be implicitly subsumed under the former two or, more probably, under their preconditions. One might also come to more precisely identify the locus of informational content, namely in the specific relation among, first, what information is present in the environment, second, what of this information is available to the perceiving organism and third, to what ends he uses it.