This chapter focuses on the historical background of the appropriate technology (AT) movement in South America, followed by exploration of the framings of AT and how these ideas were translated and reshaped in the region. It then describes the spaces and strategies where AT ideas and practices were developed, and discusses briefly some of the exemplary technologies of the movement. Some of the regional social actors and AT centres were connected to the global AT movement, linking regional developments and international opportunities. The chapter analyses this experience by focusing on the framings, strategies, knowledge and technologies involved and the dilemmas that AT cases experienced in Argentina, Chile, Brazil, Uruguay and Colombia. It explores the pathways that AT practitioners attempted to forge in South America, highlighting some of the difficulties they faced. The chapter concludes with some remarks on the legacy of AT in the region and its implications for other grassroots innovation movements.