Developing a geopolitical perspective on the knowledge-based economy requires adopting a theoretically sophisticated notion of geopolitics which transcends its pervasive orthodox connotations. Indeed, a sort of global knowledge-production industry dealing with the novelty of the relational global political order has emerged concomitantly with the so-called knowledge-based economy. The link between these imaginaries, knowledge-based economization and the restructuration of the state is however rarely debated. Questioning the teleological explanation of the progression toward the post-geopolitical geoeconomic condition is the first prerequisite for analyzing the geopolitics of the knowledge-based economy in general and knowledge-based economization in particular. Geopolitics is almost invariably conjoined with the notion of territorial control of natural resources and territorial expansion as states vie for power and seek to exert influence on other states. A quick internet search reveals that the term geopolitics is hardly ever associated with the term knowledge-based economy. The chapter also presents an overview of the key concepts discussed in this book.