ABSTRACT
A discussion of transport models following systemic, intraocular, as well as conventional eyedrop drug administration is important since ocular pharmaceuticals are often administered by more than one route. The primary advantages of direct topical drug administration include targeted drug delivery to the anterior segment of the eye and avoidance of systemic drug toxicity. Many of the disadvantages of eyedrops, such as limited penetration into vitreous and retina, compliance, and the advantages of the use of drug delivery systems, are discussed in other sections of this text.
