ABSTRACT
Optical label-free bio/chemical sensors are highly desirable for molecular analysis in many applications such as disease detection, genomics, proteomics, environmental protection, homeland security, and drug discovery. They enable detection of bio/chemical molecules without the laborious uorophore attachment processes that may interfere with the molecule’s bio/chemical functions, and allow for kinetics measurement in real time to provide important insight into molecule-molecule interaction. A well-known example is the surface plasmon resonance based bioanalytical instrument [1,2], as commercialized by Biacore, Inc. [3], which combines advantageous label-free sensing and high detection sensitivity.
