ABSTRACT
With the enormous progress in bionanotechnology recently, parenteral route has reemerged as a potential route of administration. Also, depot preparations typically designed to release the drug over period of days to months and sometimes up to years is only possible through parenteral route. This chapter provides overview of different in vitro and in vivo characterization techniques used for both controlled release and targeted parenteral drug delivery systems. Drug release studies and biodistribution studies which ultimately determine the clinical outcomes of controlled release depots and targeted drug delivery systems respectively are given special emphasis in this chapter. Lastly, important interspecies differences to be taken into considerations while selecting the appropriate animal models for in vivo studies are discussed.
