ABSTRACT
A patient-reported outcome (PRO) is a direct subjective assessment by patients about aspects of their health, including symptoms, function, emotional well-being, quality of life, utility, and satisfaction with treatment. Direct measurement of health from the patient’s perspective is an increasingly used outcome measure in clinical trial research. Thanks to US government initiatives such as the 21st Century Cures Act and the US Medicare Merit-Based Incentive Payment System, in conjunction with global initiatives, such as the E-QALY to update the quality-adjusted life-year (QALY) as an effectiveness metric to include concepts such as equity, PROs are increasingly becoming patient centered and slated to enter more mainstream use in pharmacoeconomic calculations.
