ABSTRACT
An inspiring array of various materials, provided by nature, have been finding very attractive applications in drug delivery as well as biomedical applications. locust bean gum (LBG) is obtained from the seeds of the Ceratonia siliqua and belongs to the polysaccharide group of galactomannans, which is made of mannose and galactose units, and hence, belongs to the galactomannans category. Tablets from LBG/xanthan gum hydrogels containing myoglobin were prepared by compressing these freeze-dried hydrogels. The microspheres of LBG/alginate and LBG-xanthan gum/alginate containing diclofenac sodium were formulated by employing ionic cross-linking method by means of calcium ions. In order to enhance the metoprolol bioavailability, buccoadhesive tablets of LBG or LBG and xanthan gum mixtures as matrix materials were formulated by avoiding an extensive first-pass effect of the drug. In LBG, the protein content was reported, which comprises around 32% albumin and globulin, whereas the rest 68% correspond to glutelin.
