ABSTRACT
The main emphasis in Chapter 1 is placed on quantitative mechanistic description of the respiratory drug delivery technology, including particle dispersion and flow rate dependence; interparticle interactions and aggregate strength; relationship between aerodynamic dispersion and inhaler design; performance of different carrier-based formulations and engineered particles and, in addition, fundamental and practically important aspects such as particle dissolution and solid-state stability of amorphous materials. These topics are combined with a brief review of different formulation approaches and optimization strategies for the inhalation drug products, regulatory considerations, and industrial perspectives in this important therapeutic area.
