ABSTRACT
Nanogel has emerged as one of the most flexible drug delivery systems exclusively for site-specific or time-controlled delivery of bioactive agents owing to their combining features of hydrogel and nanoparticles (NPs). Nanogel can swell by absorption of a large amount of solvent, but they do not dissolve owing to the arrangement of the chemically or physically cross-linked polymeric network. Structurally, nanogel is a class of cross-linked colloidal particles, which exhibits a behavior that extends from polymeric solutions (swollen form) to solid particles (collapsed form). They can respond to chemical stimuli (temperature, ionic strength, magnetic or electric fields, etc.), physical stimuli (temperature, electric or magnetic fields, ionic fields, etc.), and biochemical stimuli (ions, pH, specific molecules, etc.). Effective nanogel–nanogel and nanogel–drug 112interactions can be reversed by changing the degree of swelling of the particles, giving rise to a broad diversity of possibilities. Nanogel serves as an ideal drug delivery carrier, exhibiting high stability, drug loading capacity, biologic consistency and reacts to a broad range of environmental stimuli. Nowadays, targeted delivery of drug has become an issue in research with the major focus of conjugation with proteins and antitumor agents. Comprehensively, we attempt to provide synthetic methods, characterization parameters an in-depth description of elementary hypothesis, method of synthesis, characterization parameters, and mechanism of action and clinical implementation of polymeric nanogels as targeted anticancer drug delivery systems.
