ABSTRACT

Description: Aldesleukin is a modified form of human interleukin-2 (IL-2). It is produced in Escherichia coli using recombinant DNA technology and differs slightly from the natural human molecule: it lacks a serine residue at the N terminus, it has a serine residue replacing a cysteine at position 125, it is unglycosylated, and its aggregation state is different from that of the natural molecule. Nevertheless, it retains the biological activity of the natural molecule. Proleukin is provided as a lyophilized powder to be resuspended with water for injection to a proleukin concentration of 1.1 mg/ml before intravenous administration.