ABSTRACT
The frequency of radiation-induced cancer has been extensively studied in animals. However, the dose–response curves markedly vary from one tumor type to another. 1 This suggests that other environmental factors, such as cocarcinogens, tumor promoters, and antitumor promoters, may influence the processes of radiation-induced carcinogenesis, thereby shaping the dose–response curve. The factors that influence carcinogenesis include (1) age, (2) sex, (3) genetic constitution, (4) capacity to repair DNA damage, (5) carcinogen metabolism, (6) immunological status, and (7) dietary factors.
