ABSTRACT
INTRODUCTION As recently as 1950, adults aged 65 and greater constituted only 8% of the U.S. population (1). By the year 2050, the number of older adults will have increased by a factor of seven, and this sizeable subgroup will account for more than one in five U.S. citizens. By the same year, the number of older adults with major depressive disorder (MDD) is anticipated to exceed 2.5 million, creating a disease burden that will inflict suffering on many individuals and impose a significant demand on the health care system.
