ABSTRACT
Sections 4.1 and 4.2 of this chapter compile a list of the most often used acidic and basic resolving agents (50-50) as well as their physical data. The authors also comment on their availability because this is of prime practical importance. For the compounds the following data are given (if available and in this order):
Box 1: Abbreviation, molecular formula, molecular mass, structural formula, full name Box 2: Optical rotation, m.p., b.p., number of resolved compounds (NRC), solvent used for
resolution Box 3:
Chemical Abstracts
(CA) and
Beilstein
(BN) registry numbers, reference for prepa-ration, commercial sources
It must be emphasized that any optically pure chiral organic acid or base may be a candidate as resolving agent; that is, it is worthwhile to try any substance available in reasonable quantities in the given institution prepared by asymmetric synthesis or otherwise. It is therefore advisable to keep a record of any optically active chiral intermediate arising during manufacturing and regard them as potential resolving agents. In this way, useful application may be found for the unwanted enantiomer which would otherwise be discarded of a product manufactured in optically active form.
Hoeve and Wynberg
