ABSTRACT
Radionuclide therapy (RNT) has been carried out for 80 years. As with chemotherapy the treatment is systemic, although in common with external-beam radiotherapy (EBRT) it uses radiation to kill malignant cells. However, in stark contrast to EBRT, for which individual patient treatment planning has become routine practice over the last 30 years, to date neither prospective nor retrospective absorbed-dose calculations have been routinely employed. Typically, administered activities have been fixed or sometimes scaled according to body surface area or weight.
