ABSTRACT

In this chapter, we focus on the analytical separation and characterisation technique of magnetic šeld-™ow fractionation (MgFFF) and the preparative separation technique of continuous magnetic split-™ow thin channel (SPLITT) fractionation. The general concepts for both šeld-™ow fractionation (FFF) and SPLITT fractionation originated with J. Calvin Giddings of the University of Utah in 1966 and 1985, respectively. Both techniques achieve separation within thin, parallel-walled channels carrying a ™ow of ™uid with a šeld applied across the channel thickness, perpendicular to the direction of ™ow. The mechanism of separation differs, however. Separation takes place in the direction of ™ow in the case of FFF, while separation occurs across the channel thickness in the case of SPLITT fractionation.