ABSTRACT

Due to the presence of six- and seven-membered oxygen-containing heterocycles in a number of biologically important molecules, numerous natural products and pharmaceuticals, they exhibit anti-HIV, antifungal, antimicrobial, antiviral, anti-inflammatory, antidiabetic, and antioxidant properties (Mohammadi et al. 2019, Eftekhari-Sis, Sarvari Karajabad, and Haqverdi 2017). In addition, they have a wide range of uses as building blocks in organic synthesis (Eftekhari-Sis, Zirak, and Akbari 2013, Eftekhari-Sis and Zirak 2014). However, various types of one-step or multi-step synthesis of these types of heterocycles have been reported in the literature. The development of new methodologies to construct the six-membered O-heterocycles with different functional groups are of interest to synthetic and medicinal scientists.