ABSTRACT
Solid lipid nanoparticles (SLN) are colloidal particles of a lipid matrix that is solid at body temperature. SLN have been proposed as an alternative to other controlled drug delivery systems such as lipid emulsion, liposome, and polymeric nanoparticles as a result of their several advantages. In order to fully optimize the performance of SLN for anti-tumor drug delivery, it is critical to gain some understanding of their fundamental aspects. The choice of lipids is critical for SLN to achieve the desired drug loading capacity, stability, and sustained release behavior. The primary goals of cytotoxic drug therapy are to kill as many cancer cells as possible and to prevent their proliferation. Therefore, it is important to ensure that the drug released from a SLN system preserves its cytotoxicity, and the drug delivered by SLN is at least as cytotoxic to cancer cells as the conventional free drug solution.
