This chapter explores contrasting examples of the operation of a spatial division of expertise. The selection of examples is deliberate and is designed to demonstrate that the on-going development of a spatial division of expertise is occurring in both manufacturing as well as service industries. The construction of the concept of a spatial division of expertise moves the focus of analysis away from the global cities to other places in which expertise is produced and consumed. For the Dreamliner project, Boeing has created a new spatial division of expertise that is constructed around capitalizing on Boeing's internal expertise combined with that of its partners that are distributed around the globe. Airbus' economic geography is radically different to Boeing's and has its origins in the company's history. The aerospace example explores the development of spatial divisions of expertise within complex manufacturing companies that are innovating by combining intra- and inter-firm spatial divisions of expertise.