ABSTRACT

Despite the structural differences inherent to the various classes of linear motors, most are characterized as having three main functional subdomains: the head, neck, and tail. The head binds and hydrolyzes ATP. It also allows the motor to move along filament tracks and determines the direction of movement. The majority of these motors have two or more heads, which enable them to move. The tail domain determines the identity of the motor's cargo, and thus its biological function. The neck domain connects the head and tail. They also feature heavy and/or light chains that serve to stabilize the motor and contain binding sites.