ABSTRACT
OVERVIEW System installation, start-up, and commissioning are important to the successful long term operation of a pharmaceutical water purification system. Throughout this text, emphasis has been placed on proper component design, component and system specification, as well as component documentation. Incorrect component installation can result in failure of one or more components to operate in an improper manner, ultimately effecting proper operation of the entire system. Further, many small but important system operating issues may be noted during start-up. As an example, proper system start-up may identify a minor but important change to the system control logic that could have a significant effect on proper operation. Finally, proper system commissioning not only verifies correct installation and operation of components during all sequences but also provides an opportunity to verify items in the IQ and OQ prior to “official” execution. This can significantly reduce or eliminate IQ and OQ execution “deviations.”
