ABSTRACT
Piperine is an alkaloid biomolecule. Piperine is found in black pepper seeds (Piper nigrum) from plant regime. Piperine has shown broad spectrum therapeutic activities. Piperine productivity suffers due to dependence on plant regimes considering longer generation time of plant. However, extraction of piperine from plant is another big hurdle. These facts limit the productivity of piperine towards commercial implementation. Piperine biosynthetic pathway in plant is well known. However, exact enzymatic reaction mechanisms are not yet known completely. Moreover, plant based enzymes suffer due to its post translational modification and stability. Based on this current scenario, current study focuses on systems biology approaches to predict novel microbial enzymes (as alternative to plant based enzymes) towards functionalization of piperine biosynthetic pathway in microbial host. It will not only solve the issue related to plant based enzymes but it could also improve the productivity using microbial platform in near future.
