ABSTRACT
Among the reasons for the decline of the medical use of cannabis in the first half of the twentieth century were the pharmacokinetic properties of THC in oral preparations (tinctures, fatty extracts). With oral use, cannabis effects commence in a delayed and erratic manner, making it difficult to titrate the required dose. Overdosing and underdosing of medicinal cannabis preparations of unknown THC content were the inevitable consequences often described by physicians of the nineteenth century (See 1890).
