ABSTRACT

Animals are a requisite antecedent element in the clinical pathway in developing therapeutics for patients (see Chapter 9 on animal testing). This fact is of striking importance and readily acknowledged by the community of individuals involved in biomaterials testing and development for the clinical applications (Muschler et al. 2010). The humanitarian component must always take precedent when experimental animals are used. The fundamental of humane use of experimental animals for research to improve the quality of life for human patients is an integral and hallmark component of experimental animals. Consequently, animal regulatory issues are emphasized by the authors of this chapter.